Altoprev:
- As an adjunct to diet to reduce the risk of myocardial infarction (MI), unstable angina, and/or coronary revascularization procedures in patients without symptomaticcoronary heart disease (CHD), but at high risk
- Slow the progression of coronary atherosclerosis in patients with coronary heart disease as part of a treatment strategy to lower total cholesterol (Total-C) and low-density lipoprotein cholesterol (LDL-C) to target levels
- As an adjunct to diet for the reduction of elevated Total-C, LDL-C, apolipoprotein B (Apo B), and triglyceride (TG), and to increase high-density lipoprotein cholesterol (HDL-C) in patients with primary hypercholesterolemia (heterozygous familial and non-familial) and mixed dyslipidemia (Fredrickson types IIa and IIb,)
Crestor:
- Primary hyperlipidemia and mixed dyslipidemia as adjunctive therapy to diet to reduce elevated total-C, LDL-C, apolipoprotein B (ApoB), non-high-density lipoprotein cholesterol (nonHDL-C), and TG levels and to increase HDL-C in adult patients
- Heterozygous familial hypercholesterolemia (HeFH) as adjunct to diet to reduce Total-C, LDL-C and ApoB in adolescent boys and girls, who are at least one year postmenarche, 10-17 years of age, if after an adequate trial of diet therapy the following findings are present: LDL-C >190 mg/dL or >160 mg/dL and there is a positive family history of premature cardiovascular disease (CVD) or two or more other CVD risk factors
- Hypertriglyceridemia treatment of patients as adjunctive therapy to diet
- Primary dysbetalipoproteinemia (Type III Hyperlipoproteinemia) treatment of patients as an adjunct to diet
- Homozygous familial hypercholesterolemia as adjunctive therapy to other lipid-lowering treatmenets (e.g., LDL apheresis) or alone if such treatments are unavailable to reduce LDL-C, Total-C, and ApoB in adult patients
- Slow the progression of atherosclerosis as adjunctive therapy to diet in adult patients as part of a treatment strategy to lower total-C and LDL-C
- Risk reduction of MI, stroke, and arterial revascularization procedures in individuals without clinically evident coronary heart disease, but with an increased risk of cardiovascular disease based on:
- Age ≥ 50 years old in men and age ≥ 60 years old in women
- High-sensitivity C-reactive protein (hsCRP) ≥ 2 mg/L
- Presence of at least one additional cardiovascular disease risk factor such as hypertension, low HDL-C, smoking, or a family history of premature coronary heart disease
Vytorin:
- Primary (heterozygous familial and non-familial) hyperlipidemia or mixed hyperlipidemia for the reduction of elevated Total-C, LDL-C, Apo B, TG and nonHDL-C, and to increase HDL-C
- Homozygous familial hypercholesterolemia (HoFH) as an adjunct to other lipid-lowering treatments (e.g., LDL apheresis) or if such treatments are unavailable for the reduction of elevated Total-C and LDL-C
Livalo:
- Primary hyperlipidemia or mixed dyslipidemia as an adjunctive therapy to diet to reduce elevated total cholesterol (TC), low-density lipoprotein (LDL-C), apolipoprotein B (Apo B), triglycerides (TG), and to increase high-density lipoprotein cholesterol (HDL-C) in adult patients