- Management of fibromyalgia
|Drug||Dosing Regimen||Dose Limit/ Maximum Dose|
|Drug||Dosing Regimen||Authorization Limit|
The recommended dose of Savella is 100 mg/day†(50 mg PO BID).
Dosing should be titrated to 100 mg/day over a 1-week period:
Day 1: 12.5 mg once PO
Days 2-3: 25 mg/day (12.5 mg PO BID)
Days 4-7: 50 mg/day (25 mg PO BID)
After Day 7: 100 mg/day (50 mg PO BID)
May be increased to 200 mg/day (100 mg PO BID) based on individual response.
Doses above 200 mg/day have not been studied.
For patients with severe renal impairment (indicated by an estimated creatinine clearance of 5-29mL/min), the maintenance dose should be reduced by 50% to 50 mg/day (25 mg PO BID).
Savella is not recommended for patients with end-stage renal disease.
Length of benefit
Tablets: 12.5 mg, 25 mg, 50 mg, 100 mg