- Adults: Adjunctive therapy in the treatment of partial seizures
- Children: Adjunctive therapy in the treatment of partial seizures in children 6 to 17 years
|Drug||Dosing Regimen||Dose Limit/ Maximum Dose|
8-10 mg/kg PO not to exceed 600 mg/day BID
Children 2 to less than 4 years
16-20 mg/kg PO not to exceed 600 mg/day may be considered
300 mg PO BID not to exceed 2,400 mg/day
|Drug||Dosing Regimen||Authorization Limit|
Initiate with a dose of 600 mg PO QD.
Dose increases can be made at weekly intervals in 600 mg PO/day increments to achieve 1200 mg to 2400 mg/day.
Target dose is based upon weight. Titrate to target dose over two to three weeks.
Initiate with 8 mg/kg to 10 mg/kg PO QD. Increase in weekly increments of 8 mg/kg to 10 mg/kg once daily, not to exceed 600 mg.
To achieve target daily dose:
20 kg to 29 kg: 900 mg per day
29.1 kg to 39 kg: 1200 mg per day
greater than 39 kg: 1800 mg per day
Length of Benefit