• Adjunctive therapy for primary generalized tonic-clonic seizures and partial-onset seizures with or without secondary generalization in patients ≥ 13 years of age
• Conversion to monotherapy in patients ≥13 years of age with partial-onset seizures who are receiving treatment with a single antiepileptic drug (AED)

Lamictal ODT

• Adjuctive therapy for partial-onset seizures, primary generalized tonic-clonic seizures, and generalized seizures of Lennox-Gastaut syndrome in patients ≥ 2 years of age
• Conversion to monotherapy in patients ≥ 16 years of age with partial-onset seizures who are receiving treatment with carbamazepine, phenytoin, phenobarbital, primidone, or valproate as the single antiepileptic drug (AED).
• Maintenance treatment of bipolar I disorder to delay the time to occurrence of mood episodes in patients treated for acute mood episodes with standard therapy.

• Failure or clinically significant adverse effects to immediate-release lamotrigine

• Non-FDA approved indications, which are not listed in the Health Net Approved Indications and Usage Guidelines section, unless there is sufficient documentation of efficacy and safety in the published literature

• For patients being converted from immediate-release lamotrigine to Lamictal XR, the initial dose of Lamictal XR should match the total daily dose of the immediate-release lamotrigine.
• Micromedex classifies the use of lamotrigine for the Non-FDA Labeled indication of intractable convulsions in newborns as a Class IIa strength of recommendation
• Lamictal ODT: Treatment of acute manic or mixed episodes is not recommended. Effectiveness of Lamictal in the acute treatment of mood episodes has not been established.

• Lamictal XR Tablets: 25 mg, 50 mg, 100 mg, 200 mg, 250 mg, and 300 mg
• Lamictal XR Titration Kit for Patients Taking Valproate: 25 mg (21) & 50 mg (7)
• Lamictal XR Titration Kit for Patients Taking Carbamazepine, Phenytoin, Phenobarbital, or Primidone, and Not Taking Valproate: 50 mg (14) & 100 mg (14) & 200 mg (7)
• Lamictal XR Titration Kit for Patients Not Taking Carbamazepine, Phenytoin, Phenobarbital, Primidone, or Valproate:25 mg (14) & 50 mg (14) & 100 mg (7)
• Lamictal ODT Tablets: 25 mg, 50 mg, 100 mg, and 200 mg
• Lamictal ODT Titration Kit for Patients Taking Valproate: 25 mg (21) & 50 mg (7)
• Lamictal ODT Titration Kit for Patients Taking Carbamazepine, Phenytoin, Phenobarbital, or Primidone, and Not Taking Valproate: 50 mg (42) & 100 mg (14)
• Lamictal ODT Titration Kit for Patients Not Taking Carbamazepine, Phenytoin, Phenobarbital, Primidone, or Valproate:25 mg (14) & 50 mg (14) & 100 mg (7)